Estudio de utilización de antimicrobianos en pacientes adultos hospitalizados del Hospital Luis Gabriel Dávila mediante la metodología de dosis diaria definida
Keywords:
Drug utilization research, DDD, AntimicrobialsAbstract
The WHO recommends drug use studies as a quantitative tool to analyze drug consumption. The objective of this study is to analyze the consumption of antimicrobials with the defined daily dose (DDD)/(100 stays-day per year) methodology in the adult hospitalization services of the Luis G. Dávila Hospital between 2014 to 2016, and to compare these data with other studies. The present work is an observational, descriptive, longitudinal and retrospective study in which the ATC DDD/100 stays-days were evaluated by months, years and by antimicrobial groups, obtaining an average value of 92,6. Seasonal behaviors and a trend of lower consumption of antimicrobials were also observed, due to the implementation of clinical protocols and guidelines, as well as pharmaceutical interventions.
References
Organización Mundial de la Salud. Plan de acción mundial sobre la resistencia a los antimicrobianos. [Internet].; 2016 [Consultado 28 feb. 2024]. Disponible en:
https://iris.who.int/bitstream/handle/10665/255204/9789243509761-spa.pdf?sequence=1
Norwegian Institute of Public Health. WHO Collaborating Centre for Drug Statistics Methodology. [Internet]. [consultado 18 feb 2024]. Disponible en: https://www.whocc.no/atc_ddd_index/.
Bavestrello. Implementación de evaluación de PROA. Presentación power point de resultados
de estudio DDD. Viña del Mar: Hospital Clínica Reñaca; 2017.
Fatma B, Safak K, Recep T, Serda G, Ozcan D, Saim D, et al. Analysis of antimicrobial consumption and cost in a teaching hospital. Journal of Infection and Public Health. 2014 Apr; 7(2):161-169. doi: 10.1016/j.jiph.2013.09.007
Jabeen , Ullah , Khalid J, Samad Z. Estimating antibiotics consumption in a tertiary care hospital in Islamabad using a WHO’s defined daily dose methodology. Aric Journal. 2023 Nov 23;2-12. doi: 10.1186/s13756-023-01311-2
Cabrera A S, Sosa L, Arteta Z, Seija V, Mateos S, Perna A, et al. Uso racional de antimicrobianos en el departamento. Revista Chilena de Infectología. 2012; 1(29):7-13. doi: 10.4067/S0716-10182012000100001
Collado R, Losa JE, Alvaro EA, Toro P, Moreno L, Perez M. Evaluación del consumo de antimicrobianos mediante DDD/100 estancias versus DDD/100 altas en la implantación de un Programa de Optimización del Uso de Antimicrobianos. Quimioter. 2015; 6(28):317-321.
Nebyu A, Dawit GW, Yohana HB. Antibiotic consumption study in two hospitals in Asmara from 2014 to 2018 using WHO’s defined daily dose (DDD) methodology. Plos One. 2020 Jul 02; 15(7):1-11. doi: 10.1371/journal.pone.0233275
Arup KM, Sushil S, Sumit R, Madhavrao C, Gaurav R, Srinivasa RK, et al. Defined Daily Dose (DDD): An Essential Metricin the Antimicrobial Stewardship Programmes (AMSPs) in the Healthcare Sector. Journal of Antimicrobial Stewardship Practices and Infectious diseases JASPI. 2023 Dec; 1(1):27-33.
Pérez Báez , Sierra Díaz D, Romero Rodríguez , Trujillo Rodríguez. Consumo de antibióticos en dos servicios hospitalarios. Revista Electrónica Medimay. 2020 Dec; 27(4):473-480.
Valles J, Fernández S, Cortés E, Morón A, Fondevilla E, Oliva JC, et al. Comparisonofthedefineddailydoseanddaysoftreatmentmethodsforevaluatingtheconsumptionofantibioticsandantifungalsintheintensivecareunit. Medicina Intensiva. 2019 Jun 14;:294-300. doi: 10.1016/j.medin.2019.06.008
Vega , Fontana , Iturrieta , Segovia , Rodríguez , Agüero. Consumo de antimicrobianos en la Unidad de Terapia Intensiva. Revista Chilena de Infectología. 2015; 32(3):259-265. doi: 10.4067/S0716-10182015000400001
Först , De Con K, Weber N, Bordé , Querbach , Kleideiter , et al. Validation of adapted daily dose definitions for hospital antibacterial drug use evaluation: a multicentre study. Journal of Antimicrobial Chemotherapy. 2017 Oct 10; 79(2):2931-2937. doi: 10.1093/jac/dkx244
